ABSTRACT
Introduction: The implementation of public health and social measures (PHSMs) was an effective option for controlling coronavirus disease 2019 (COVID-19). However, evidence is needed to evaluate these PHSMs' effects on the recently emerged variant Omicron. Methods: This study investigated variant Omicron BA.2's outbreak in Ruili City, Yunnan Province, China. The disease transmission dynamics, spatiotemporal interactions, and transmission networks were analyzed to illustrate the effect of PHSM strategies on Omicron spread. Results: A total of 387 cases were related to the outbreak. The time-varying reproduction number was synchronized with PHSM strategies. Spatiotemporal clustering strength presented heterogeneity and hotspots. Restricted strategies suppressed temporal and spatial relative risk compared with routine and upgraded strategies. The transmission network presented a steeper degree distribution and a heavier tail under upgraded strategies. Phase transformation and distinctive transmission patterns were observed from strategy-stratified subnetworks. Conclusions: The tightened response strategy contained reproduction of the virus, suppressed spatiotemporal clustering, and reshaped the networks of COVID-19 Omicron variant transmission. As such, PHSMs against Omicron are likely to benefit future responses as well.